5-ヒドロキシペンタンヒドラジドの結晶構造およびHirshfeld表面解析
This study reports the synthesis and structural characterization of 5-hydroxypentanehydrazide, an aliphatic carboxyhydrazide compound prepared by reacting a lactone with hydrazine hydrate. Colorless prismatic single crystals were obtained and found to belong to the orthorhombic space group P2. Supramolecular analysis revealed medium-to-strong intermolecular hydrogen bonding interactions involving both the hydroxyl and hydrazide functional groups. Three-dimensional crystal packing was further examined using Hirshfeld surface analysis and fingerprint plots, which identified weak H···H and C···H contacts. The compound is noted as a potential intermediate for derivatives capable of inhibiting Mycobacterium tuberculosis catalase-peroxidase (KatG), thereby contributing to pathogen elimination.
The compound's hydroxyl and hydrazide moieties can be derivatized to yield analogs that inhibit Mycobacterium tuberculosis catalase-peroxidase (KatG), potentially leading to pathogen death.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/38721432