水素医学の現状・課題・将来展望：生物学的機序・代謝挙動・デリバリー技術の包括的レビュー
Molecular hydrogen (H₂) possesses several distinctive properties—broad-spectrum anti-inflammatory activity, favorable biosafety profile, and high tissue permeability—that underpin its potential in diseases driven by inflammation and oxidative stress. This review synthesizes current knowledge across three domains: (1) biological mechanisms, including the identification of H₂ molecular targets and the challenge of accounting for its diverse cellular effects; (2) metabolic behavior, encompassing detection methodologies and experimental evidence—obtained with a newly developed H₂ molecular bioprobe—demonstrating H₂'s capacity to cross biological barriers; and (3) delivery strategies, tracing the evolution from passive H₂ carrier materials to hydrolytic and catalytic H₂-generating systems designed to improve efficacy. The review concludes by delineating priority directions for future research in hydrogen medicine.
H₂ is proposed to selectively scavenge highly reactive oxygen species—including hydroxyl radicals and peroxynitrite—through interaction with specific molecular targets, thereby broadly suppressing inflammatory signaling cascades.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/41971791