Alzheimer's disease

27 papers

Research evidence summary

Q: Does molecular hydrogen help with Alzheimer's disease?

A: Of 27 peer-reviewed papers, 13 reported a positive effect (the most common), 2 limited/mixed, 0 negative, 12 not assessed. Study mix: 2 human (1 RCT), 13 animal/basic, 11 meta-analysis or synthesis. The most studied delivery route is mixed routes. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	2	of which RCT	1
Animal/basic	13	Synthesis/meta	11
Reported effect	positive 13 ・ limited/mixed 2 ・ negative 0 ・ not assessed 12

Read the safety notes →

Delivery-method distribution

mixed routes: 8 hydrogen-rich water: 6 inhalation: 5 not specified: 4 in vitro: 3 injection / infusion: 1

Neuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
2026 ・ Antioxidants (Basel) ・ PMID 41897548

inhalation positive animal study
Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models.
2025 ・ Int J Mol Sci ・ PMID 40725167

inhalation positive animal study
Hydrogen-Bonded Organic Framework-Based NIR-II Activated Hydrogen Production for Treatment of Alzheimer's Disease Model Mice.
2025 ・ Small ・ PMID 39989154

in vitro positive animal study
Molecular hydrogen inhibits neuroinflammation and ameliorates depressive-like behaviors and short-term cognitive impairment in senescence-accelerated mouse prone 8 mice.
2025 ・ Behav Brain Res ・ PMID 39522774

hydrogen-rich water positive animal study
Hydrogen as an innovative nootropic in health and disease.
2025 ・ Nutr Health ・ PMID 39042916

mixed routes not assessed review
Emerging role of antioxidants in Alzheimer's disease: Insight into physiological, pathological mechanisms and management.
2024 ・ Pharm Sci Adv ・ PMID 41550171

not specified not assessed review
Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
2024 ・ Front Aging Neurosci ・ PMID 39839307

hydrogen-rich water positive animal study
Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial.
2023 ・ Antioxidants (Basel) ・ PMID 37371971

inhalation positive human observational study
Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.
2023 ・ Antioxidants (Basel) ・ PMID 37237854

mixed routes not assessed review
An NIR-Driven Upconversion/CN/CoP Photocatalyst for Efficient Hydrogen Production by Inhibiting Electron-Hole Pair Recombination for Alzheimer's Disease Therapy.
2023 ・ ACS Nano ・ PMID 36688477

in vitro positive animal study
Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.
2023 ・ Mol Neurobiol ・ PMID 36567361

mixed routes not assessed review
Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?
2022 ・ Int J Mol Sci ・ PMID 35743035

mixed routes not assessed review
Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.
2022 ・ Neural Regen Res ・ PMID 34269217

hydrogen-rich water positive animal study
Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model.
2021 ・ Int J Mol Sci ・ PMID 34948107

inhalation positive animal study
Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.
2021 ・ Cell Mol Life Sci ・ PMID 34643743

not specified not assessed review
Montelukast microsuspension with hypromellose for improved stability and oral absorption.
2021 ・ Int J Biol Macromol ・ PMID 34051251

not specified positive animal study
Neuroprotective and Preventative Effects of Molecular Hydrogen.
2021 ・ Curr Pharm Des ・ PMID 33076798

hydrogen-rich water not assessed review
Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
2021 ・ Pediatr Res ・ PMID 32505123

inhalation not assessed review
Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease.
2019 ・ Biomaterials ・ PMID 30703744

injection / infusion positive animal study
Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.
2018 ・ Free Radic Res ・ PMID 29683360

hydrogen-rich water mixed animal study
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.
2018 ・ Curr Alzheimer Res ・ PMID 29110615

mixed routes mixed human randomized controlled trial
Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.
2017 ・ J Clin Biochem Nutr ・ PMID 28751802

mixed routes not assessed review
Molecular Hydrogen as a Neuroprotective Agent.
2017 ・ Curr Neuropharmacol ・ PMID 27281176

mixed routes not assessed review
Design and optimization of selective azaindole amide M1 positive allosteric modulators.
2016 ・ Bioorg Med Chem Lett ・ PMID 26631313

not specified not assessed other
Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.
2015 ・ Chem Biol Interact ・ PMID 26271894

in vitro positive in vitro study