水素結合有機フレームワークを用いたNIR-II光触媒による水素発生とアルツハイマー病モデルマウスへの効果
Oxidative stress plays a central role in neuronal loss and cognitive deterioration associated with Alzheimer's disease (AD). This study reports the rational design of hydrogen-bonded organic framework (HOF) composites capable of sustained near-infrared II (NIR-II) photocatalytic hydrogen generation for neuroinflammation relief in AD model mice. The composite integrates three functional components: porphyrin as a photocatalyst, DSM (a NIR-II-absorbing pyridinium hemicyanine dye) as an energy transducer, and platinum nanoparticles as a co-catalyst. Upon NIR-II laser irradiation, DSM activates porphyrin to generate reductive hydrogen in situ. Porphyrin selectively coordinates with Cu ions accumulated in Aβ plaques, further enhancing hydrogen evolution. Surface grafting of the KD8 peptide (KLVFFAED) improves blood-brain barrier permeability in vivo. In AD model mice, the system reduced neuroinflammation and restored cognitive function, demonstrating a photocatalytic HOF-based strategy for continuous in vivo hydrogen accumulation.
Under NIR-II laser irradiation, DSM transfers energy to porphyrin, which selectively binds Cu ions in Aβ plaques and catalytically generates hydrogen in situ. The produced hydrogen scavenges reactive oxygen species, thereby suppressing neuroinflammation and oxidative stress in the AD brain.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/39989154