Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
ゼブラフィッシュのアルツハイマー病モデルにおける水素水の効果：酸化ストレス・炎症・腸脳軸への影響
Abstract
Using a zebrafish model of Alzheimer's disease (AD) induced by aluminum chloride exposure, this study examined the effects of hydrogen-rich water (HRW) delivered via a nanobubble device. Behavioral assessments, ELISA, hematoxylin-eosin staining, ROS and neutrophil fluorescence labeling, and 16S rRNA sequencing were applied. HRW significantly ameliorated cognitive impairment and depression-like behavior, reduced amyloid-beta (Aβ) deposition (p<0.0001), and modulated hepatic soluble epoxide hydrolase (sEH) levels (p<0.05). Neuroinflammation and oxidative stress were also attenuated. Additionally, HRW restored gut microbiota balance, lowering the abundance of bacteria associated with AD pathology. These results indicate that HRW exerts multi-target effects encompassing antioxidant, anti-inflammatory, and gut-brain axis regulatory actions in this AD model.
Mechanism
HRW suppressed Aβ-induced ROS generation and oxidative stress, modulated hepatic soluble epoxide hydrolase (sEH) to reduce neuroinflammation, and restored gut microbiota composition, thereby influencing the gut-brain axis in an AD zebrafish model.
Bibliographic
- Authors
- He J, Xu P, Xu T, Yu HS, Wang L, Chen R, et al.
- Journal
- Front Aging Neurosci
- Year
- 2024
- PMID
- 39839307
- DOI
- 10.3389/fnagi.2024.1515092
- PMC
- PMC11746902
Tags
Delivery context
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
Safety notes
See also: