H₂
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Safety Notes
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atherosclerosis
17 papers
Delivery-method distribution
hydrogen-rich water: 7
mixed routes: 6
not specified: 1
injection / infusion: 1
inhalation: 1
in vitro: 1
Consumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
2026 ・ Life Sci ・ PMID 42069299
hydrogen-rich water
positive
animal study
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis.
2024 ・ Int J Endocrinol Metab ・ PMID 39839806
hydrogen-rich water
mixed
meta-analysis
Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases.
2024 ・ Rev Cardiovasc Med ・ PMID 39077646
mixed routes
not assessed
review
The role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease.
2024 ・ Eur J Pharmacol ・ PMID 38615891
not specified
not assessed
review
Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.
2023 ・ Front Nutr ・ PMID 37521410
hydrogen-rich water
mixed
human case report
Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.
2023 ・ Cell Mol Life Sci ・ PMID 37269385
mixed routes
not assessed
review
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis.
2023 ・ Pharmaceuticals (Basel) ・ PMID 37259294
hydrogen-rich water
positive
meta-analysis
Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside.
2023 ・ Pharmaceuticals (Basel) ・ PMID 37111299
mixed routes
not assessed
review
Effects of hydrogen as adjuvant treatment for unstable angina.
2021 ・ Exp Biol Med (Maywood) ・ PMID 33899541
mixed routes
positive
human randomized controlled trial
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
2020 ・ PLoS One ・ PMID 32470022
hydrogen-rich water
positive
human randomized controlled trial
Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
2020 ・ PLoS One ・ PMID 32302306
inhalation
positive
animal study
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.
2018 ・ Sci Rep ・ PMID 30429524
hydrogen-rich water
positive
animal study
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
2015 ・ Free Radic Biol Med ・ PMID 26117323
mixed routes
positive
animal study
Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.
2013 ・ Curr Pharm Des ・ PMID 23859555
mixed routes
not assessed
review
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.
2013 ・ Med Gas Res ・ PMID 23448206
in vitro
positive
in vitro study
Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
2012 ・ Arch Oral Biol ・ PMID 22607937
hydrogen-rich water
positive
animal study
Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.
2012 ・ Atherosclerosis ・ PMID 22153150
injection / infusion
positive
animal study