LDL受容体欠損マウスの大動脈における血管老化に対する水素水摂取の抑制効果
Atherosclerosis, the principal driver of arteriosclerosis, is characterized as a chronic inflammatory process initiated by arterial endothelial dysfunction, in which oxidized LDL plays a central role. Cellular senescence has recently been implicated in atherosclerosis progression, with the senescence-associated secretory phenotype (SASP) contributing to disease advancement. Using LDL receptor-deficient mice fed a high-fat diet (HFD) for 13 weeks as an atherosclerosis model, this study examined the effects of continuous hydrogen-rich water (HW) administration. Compared with HFD mice receiving control water, HFD mice given HW showed a significant reduction in the number of endothelial cells within atheromas expressing the senescence markers p16 and p21. Additionally, macrophage infiltration and Tnfα expression within atheromas were both diminished in the HW group. These findings indicate that HW intake may suppress vascular aging processes associated with atherosclerotic lesion development.
Hydrogen-rich water reduces oxidative stress and inflammation, thereby suppressing expression of senescence markers p16 and p21 in atheroma endothelial cells and decreasing macrophage infiltration along with Tnfα production.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/30429524