H₂
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anti-inflammatory
743 papers
Delivery-method distribution
hydrogen-rich water: 254
inhalation: 140
mixed routes: 129
not specified: 61
in vitro: 61
injection / infusion: 60
topical application: 17
animal model: 15
hydrogen bath: 6
Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress.
2020 ・ Exp Ther Med ・ PMID 32537002
animal model
positive
animal study
Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury in Rats.
2020 ・ J Bioenerg Biomembr ・ PMID 32472432
hydrogen-rich water
positive
animal study
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
2020 ・ PLoS One ・ PMID 32470022
hydrogen-rich water
positive
human randomized controlled trial
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
2020 ・ Int J Oral Maxillofac Surg ・ PMID 32451233
mixed routes
positive
animal study
Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32447221
inhalation
positive
animal study
Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.
2020 ・ F1000Res ・ PMID 32399209
hydrogen bath
positive
human case report
Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
2020 ・ Brain Res ・ PMID 32348775
inhalation
positive
animal study
Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
2020 ・ PLoS One ・ PMID 32302306
inhalation
positive
animal study
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.
2020 ・ Diabetes Metab Syndr Obes ・ PMID 32273740
hydrogen-rich water
positive
human randomized controlled trial
Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method.
2020 ・ Front Med (Lausanne) ・ PMID 32266279
hydrogen-rich water
positive
animal study
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32058932
inhalation
positive
animal study
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
2020 ・ Sci Rep ・ PMID 32029879
mixed routes
positive
human observational study
Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.
2020 ・ Microbiol Mol Biol Rev ・ PMID 31996394
not specified
not assessed
review
Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.
2020 ・ FASEB J ・ PMID 31930571
injection / infusion
positive
animal study
Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis.
2020 ・ Med Sci Monit ・ PMID 31927559
injection / infusion
positive
animal study
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
2020 ・ BMC Cancer ・ PMID 31924176
hydrogen-rich water
positive
animal study
Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice.
2020 ・ Chin J Integr Med ・ PMID 31919748
hydrogen-rich water
positive
animal study
Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.
2020 ・ Biochem Biophys Res Commun ・ PMID 31810604
in vitro
positive
in vitro study
Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation.
2020 ・ J Thorac Cardiovasc Surg ・ PMID 31780065
injection / infusion
positive
animal study
Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
2020 ・ Mol Med Rep ・ PMID 31746358
injection / infusion
positive
animal study
Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in sedentary rats.
2020 ・ Neurosci Lett ・ PMID 31715290
inhalation
positive
animal study
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
2020 ・ Curr Mol Med ・ PMID 31702499
hydrogen-rich water
positive
animal study
Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens.
2020 ・ Prog Neuropsychopharmacol Biol Psychiatry ・ PMID 31629777
injection / infusion
positive
animal study
Hydrogen water alleviates obliterative airway disease in mice.
2020 ・ Gen Thorac Cardiovasc Surg ・ PMID 31468277
hydrogen-rich water
positive
animal study
Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.
2019 ・ F1000Res ・ PMID 32595937
topical application
positive
human case report
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