水素水がマウス閉塞性気道疾患モデルに及ぼす抑制効果
Bronchiolitis obliterans syndrome following lung transplantation is associated with chronic airway inflammation and remains a major cause of post-transplant mortality. Using a heterotopic tracheal allograft model in which BALB/c donor tracheas were transplanted into C57BL/6 recipients, this study examined the daily administration of hydrogen-rich water (10 ppm) without immunosuppression. Histological evaluation at day 14 revealed reduced airway occlusion in the hydrogen water group compared with tap water controls. Immunohistochemical analysis showed an elevated CD4/CD3 ratio in allografts at day 14. ELISA data from day 7 indicated decreased interleukin-6 levels alongside increased forkhead box P3 expression, pointing to enhanced regulatory T cell activity. No significant differences were detected at days 7 or 21. These findings suggest that hydrogen-rich water can attenuate mid-term obliterative airway disease progression through anti-inflammatory and antioxidant mechanisms involving Treg activation.
Hydrogen-rich water reduced pro-inflammatory cytokine IL-6 and upregulated FoxP3 expression, indicating enhanced regulatory T cell activity. These combined anti-inflammatory and antioxidant actions are proposed to underlie the suppression of obliterative airway disease progression.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/31468277