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Nrf2 pathway
106 papers
Delivery-method distribution
hydrogen-rich water: 32
mixed routes: 21
inhalation: 21
in vitro: 14
not specified: 8
injection / infusion: 7
animal model: 2
topical application: 1
Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.
2021 ・ Oxid Med Cell Longev ・ PMID 34646423
mixed routes
not assessed
review
An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions.
2021 ・ J Integr Neurosci ・ PMID 34645100
hydrogen-rich water
not assessed
review
High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice.
2021 ・ Int Immunopharmacol ・ PMID 34634688
inhalation
positive
animal study
Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.
2021 ・ Int J Mol Sci ・ PMID 34281264
not specified
not assessed
review
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
2021 ・ Invest Ophthalmol Vis Sci ・ PMID 34196654
mixed routes
positive
animal study
Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice.
2021 ・ Life Sci ・ PMID 34052293
injection / infusion
positive
animal study
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
2021 ・ Biochem Biophys Res Commun ・ PMID 33340760
hydrogen-rich water
positive
animal study
Biological Responses to Hydrogen Molecule and its Preventive Effects on Inflammatory Diseases.
2021 ・ Curr Pharm Des ・ PMID 32981496
mixed routes
not assessed
review
Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine.
2021 ・ Curr Pharm Des ・ PMID 32954996
not specified
not assessed
review
Molecular Hydrogen Application in Stroke: Bench to Bedside.
2021 ・ Curr Pharm Des ・ PMID 32940172
mixed routes
not assessed
review
Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions.
2021 ・ Curr Pharm Des ・ PMID 32767925
not specified
not assessed
review
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
2021 ・ Shock ・ PMID 32590694
inhalation
positive
animal study
Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.
2020 ・ Antioxidants (Basel) ・ PMID 33333951
mixed routes
not assessed
review
Molecular hydrogen alleviates brain injury and cognitive impairment in a chronic sequelae model of murine polymicrobial sepsis.
2020 ・ Exp Brain Res ・ PMID 33052428
inhalation
positive
animal study
Inhaled Hor CODo Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model.
2020 ・ Int J Mol Sci ・ PMID 32948011
inhalation
null
animal study
Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32447221
inhalation
positive
animal study
Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
2020 ・ Brain Res ・ PMID 32348775
inhalation
positive
animal study
Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.
2020 ・ J Invest Dermatol ・ PMID 32234461
in vitro
positive
in vitro study
Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.
2020 ・ J Biochem Mol Toxicol ・ PMID 32040235
hydrogen-rich water
positive
animal study
Transcriptome analysis reveals insight into molecular hydrogen-induced cadmium tolerance in alfalfa: the prominent role of sulfur and (homo)glutathione metabolism.
2020 ・ BMC Plant Biol ・ PMID 32019510
hydrogen-rich water
positive
in vitro study
Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.
2019 ・ F1000Res ・ PMID 32595937
topical application
positive
human case report
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
2019 ・ J Bioenerg Biomembr ・ PMID 31768722
hydrogen-rich water
positive
animal study
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
2019 ・ Molecules ・ PMID 31159153
mixed routes
not assessed
review
Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.
2019 ・ Can J Physiol Pharmacol ・ PMID 30970215
mixed routes
not assessed
review
Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease.
2019 ・ Biomaterials ・ PMID 30703744
injection / infusion
positive
animal study
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