四肢虚血再灌流誘発急性肺傷害に対する水素の保護効果：マウスモデルにおける検討
Limb ischaemia/reperfusion (LIR) can trigger systemic inflammatory responses and multi-organ dysfunction. This study examined the effects of hydrogen-saturated saline administered intraperitoneally in a murine LIR-induced acute lung injury (ALI) model. Hydrogen administration reduced malondialdehyde (MDA) levels and elevated superoxide dismutase (SOD) activity in lung tissue. Activation of the Nrf2 signalling pathway, along with upregulation of HO-1 and NQO1, was observed following hydrogen administration. Autophagy-related molecular markers were suppressed, and ceramide accumulation in lung tissue caused by LIR was altered by hydrogen. These findings indicate that hydrogen exerts protective effects on LIR-induced ALI through modulation of antioxidant defence mechanisms and autophagy regulation.
Hydrogen activates the Nrf2/HO-1/NQO1 antioxidant pathway, suppresses excessive autophagy induction, and modulates ceramide accumulation in lung tissue, collectively reducing LIR-induced acute lung injury.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/34052293