分子状水素による前症状疾患（未病）への新たな防御的アプローチ：慢性炎症抑制機序のレビュー
Pre-symptomatic disease, known in Japanese medicine as 'mibyou', describes a condition in which pathological processes are underway before clinical symptoms emerge. Chronic inflammation, driven by dysregulated release of pro-inflammatory cytokines from neutrophils and macrophages of the innate immune system, represents a major category of such conditions. This review examines evidence that molecular hydrogen (H2) can counteract chronic inflammation by scavenging hydroxyl radicals (·OH), a mitochondria-derived reactive oxygen species. By reducing oxidative stress, H2 interferes with upstream mechanisms of chronic inflammation, including NLRP3 inflammasome activation. The review surveys applications of H2 as a preventive agent across multiple inflammatory disease states in their pre-symptomatic phase, arguing that H2 may offer a means of addressing pathological progression that conventional medicine currently cannot detect or intervene upon at this early stage.
H2 selectively neutralizes mitochondria-derived hydroxyl radicals (·OH), thereby reducing oxidative stress and suppressing NLRP3 inflammasome activation, which collectively attenuates the pathological cascade underlying chronic inflammation.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/34281264