H₂
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oxidative stress
899 papers
Delivery-method distribution
hydrogen-rich water: 313
inhalation: 153
mixed routes: 150
in vitro: 103
injection / infusion: 72
not specified: 66
topical application: 19
animal model: 15
hydrogen bath: 8
Hydrogen as a new class of radioprotective agent.
2013 ・ Int J Biol Sci ・ PMID 24155664
mixed routes
not assessed
review
Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages.
2013 ・ Int J Surg ・ PMID 24148794
in vitro
positive
in vitro study
Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).
2013 ・ Int J Mol Sci ・ PMID 24132155
hydrogen-rich water
not assessed
review
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
2013 ・ Clin Transl Sci ・ PMID 24127924
hydrogen-rich water
mixed
human randomized controlled trial
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.
2013 ・ Free Radic Biol Med ・ PMID 23954468
hydrogen-rich water
positive
animal study
Molecular hydrogen is involved in phytohormone signaling and stress responses in plants.
2013 ・ PLoS One ・ PMID 23951075
hydrogen-rich water
positive
other
Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.
2013 ・ Curr Pharm Des ・ PMID 23859555
mixed routes
not assessed
review
Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.
2013 ・ Adv Exp Med Biol ・ PMID 23852510
inhalation
not assessed
human observational study
Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water.
2013 ・ J Hazard Mater ・ PMID 23846121
hydrogen-rich water
positive
in vitro study
Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.
2013 ・ Int J Ophthalmol ・ PMID 23826519
in vitro
positive
in vitro study
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
2013 ・ Med Gas Res ・ PMID 23816239
injection / infusion
positive
human case report
Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.
2013 ・ Int J Radiat Biol ・ PMID 23786587
in vitro
positive
in vitro study
Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
2013 ・ J Surg Res ・ PMID 23773716
injection / infusion
positive
animal study
Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
2013 ・ Med Gas Res ・ PMID 23742229
not specified
not assessed
review
The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.
2013 ・ Med Gas Res ・ PMID 23680032
mixed routes
not assessed
review
The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
2013 ・ Acta Neurochir Suppl ・ PMID 23564105
inhalation
positive
animal study
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.
2013 ・ Med Gas Res ・ PMID 23448206
in vitro
positive
in vitro study
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
2013 ・ Mol Neurobiol ・ PMID 23436141
not specified
not assessed
review
Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
2013 ・ Mov Disord ・ PMID 23400965
hydrogen-rich water
positive
human randomized controlled trial
Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
2013 ・ Urology ・ PMID 23374763
hydrogen-rich water
null
human randomized controlled trial
Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production.
2013 ・ Dig Dis Sci ・ PMID 23371012
mixed routes
positive
animal study
A novel method of preserving cardiac grafts using a hydrogen-rich water bath.
2013 ・ J Heart Lung Transplant ・ PMID 23273745
hydrogen bath
positive
animal study
Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
2013 ・ Anesthesiology ・ PMID 23221861
inhalation
positive
animal study
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
2013 ・ Mol Cell Biochem ・ PMID 23212446
in vitro
positive
in vitro study
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
2013 ・ Osteoporos Int ・ PMID 22648000
mixed routes
positive
animal study
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