慢性B型肝炎患者における水素水摂取が酸化ストレス・肝機能・ウイルス量に与える影響：無作為化対照試験
A randomized controlled trial enrolled 60 patients with chronic hepatitis B (CHB), allocating them to either standard care alone or standard care supplemented with oral hydrogen-rich water (HRW; 1200–1800 mL/day in two divided doses) for six weeks. Thirty healthy individuals served as a reference group. At baseline, CHB patients exhibited markedly elevated oxidative stress and impaired hepatic function compared with healthy controls. Following the intervention, oxidative stress markers remained unchanged in the standard-care group but showed significant improvement in the HRW group. Both groups demonstrated improvements in liver function indices and reductions in HBV DNA levels, yet no statistically significant between-group differences were observed for these two endpoints. The findings indicate that HRW effectively reduces oxidative stress in CHB patients, while its impact on hepatic function and viral load requires confirmation through longer-duration studies.
HRW is thought to selectively neutralize reactive oxygen species, thereby reducing systemic oxidative stress in patients with chronic hepatitis B without directly suppressing viral replication.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/24127924