reactive oxygen species

774 papers

Research evidence summary

Q: Does molecular hydrogen help with reactive oxygen species?

A: Of 774 peer-reviewed papers, 515 reported a positive effect (the most common), 50 limited/mixed, 5 negative, 203 not assessed. Study mix: 94 human (50 RCT), 456 animal/basic, 153 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	94	of which RCT	50
Animal/basic	456	Synthesis/meta	153
Reported effect	positive 515 ・ limited/mixed 50 ・ negative 5 ・ not assessed 203

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 224 in vitro: 135 inhalation: 133 mixed routes: 118 not specified: 75 injection / infusion: 58 topical application: 14 animal model: 12 hydrogen bath: 5

H-dependent modulation of tetrahydromethanopterin S-methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei.
2026 ・ FEBS J ・ PMID 41689349

in vitro positive in vitro study
Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats.
2026 ・ Biomater Adv ・ PMID 41671925

injection / infusion positive animal study
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
2026 ・ J Transl Med ・ PMID 41654898

mixed routes positive animal study
Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses.
2026 ・ Front Nutr ・ PMID 41641160

hydrogen-rich water positive animal study
Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis.
2026 ・ World J Orthop ・ PMID 41608485

mixed routes positive review
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice.
2026 ・ Int J Mol Sci ・ PMID 41596287

mixed routes positive animal study
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
2026 ・ Sci Rep ・ PMID 41582106

inhalation positive human observational study
Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
2026 ・ Aesthetic Plast Surg ・ PMID 41545661

hydrogen-rich water positive human randomized controlled trial
Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.
2026 ・ Clin Exp Immunol ・ PMID 41533764

mixed routes positive animal study
Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?
2026 ・ Redox Biol ・ PMID 41496215

not specified not assessed review
Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review.
2026 ・ Acta Paediatr ・ PMID 41482991

not specified not assessed review
Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.
2026 ・ In Vivo ・ PMID 41482402

hydrogen-rich water positive human case report
Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
2026 ・ In Vivo ・ PMID 41482388

hydrogen-rich water positive human case report
Emerging Clinical Applications for Molecular Hydrogen.
2026 ・ Respir Care ・ PMID 41449652

inhalation not assessed review
Osteoimmunometabolic modulation via hydrogen-self-supplying magnesium-reinforced collagen membrane for enhanced guided bone regeneration.
2026 ・ Biomaterials ・ PMID 41435455

in vitro positive animal study
Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models.
2026 ・ Reprod Toxicol ・ PMID 41421768

hydrogen-rich water positive animal study
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury.
2026 ・ Exp Neurol ・ PMID 41386344

inhalation positive animal study
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling.
2026 ・ Bioact Mater ・ PMID 41334374

in vitro positive in vitro study
Postharvest preservation of chestnuts: Combined application of hydrogen-rich water and a carboxymethyl chitosan/sodium alginate composite coating.
2026 ・ Int J Biol Macromol ・ PMID 41314584

hydrogen-rich water positive other
Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.
2026 ・ Free Radic Biol Med ・ PMID 41308938

in vitro positive animal study
Gas Therapies for Neuro-Protection.
2026 ・ Crit Care Clin ・ PMID 41260719

inhalation not assessed review
Advances in hydrogen delivery strategies for therapeutic applications.
2026 ・ Adv Drug Deliv Rev ・ PMID 41232804

mixed routes not assessed review
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
2026 ・ J Nutr Biochem ・ PMID 41207540

hydrogen-rich water positive animal study
Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy.
2026 ・ Pain ・ PMID 41143867

hydrogen-rich water positive animal study
Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
2026 ・ Med Gas Res ・ PMID 40826940

mixed routes positive review