人工皮膚モデルを用いたUVA誘発光老化に対する水素ガスの予防効果のトランスクリプトーム解析
Using an artificial skin construct, this in vitro study examined whether 1.3% hydrogen gas could counteract UVA-induced photoaging. Artificial skin was exposed to UVA at 7 or 10.5 J/cm²/day over three cycles, with or without concurrent hydrogen gas incubation. At 7 J/cm²/day, photoaging-associated transcriptomic changes were prominent despite minimal epidermal morphological alterations, whereas 10.5 J/cm²/day produced epidermal hypoplasia with excessive apoptosis but limited gene expression changes. Hydrogen gas modulated multiple biological pathways at the 7 J/cm²/day dose, including NRF2-mediated antioxidant responses, NF-κB1-RelA-mediated inflammatory signaling, and p53-dependent cellular senescence. These findings suggest that hydrogen diffusing through the skin surface may reduce UVA-induced cellular stress and senescence, providing preliminary transcriptomic evidence to support future translational investigations.
Hydrogen gas diffuses through the skin surface and modulates UVA-induced oxidative and senescence responses by activating NRF2-mediated antioxidant signaling, regulating NF-κB1-RelA inflammatory pathways, and suppressing p53-dependent cellular senescence.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/41749059