水素分子は脊髄・扁桃体における性差および部位依存的な中枢メカニズムを介してノシプラスティック疼痛とうつ様行動を改善する
Using a reserpine-induced murine model of fibromyalgia, this study examined how hydrogen-rich water (HRW) affects nociceptive hypersensitivity and depressive-like behaviors in male and female C57BL/6 mice, with attention to region- and sex-specific molecular mechanisms. Repeated reserpine administration produced persistent mechanical allodynia, thermal hyperalgesia, cold allodynia, and depressive-like behaviors in both sexes, with cold allodynia appearing earlier in females. HRW progressively reduced mechanical and thermal hypersensitivity, rapidly eliminated cold allodynia—with greater efficacy in females—and normalized depressive-like behaviors in both sexes. Molecular analyses revealed that HRW lowered spinal oxidative stress and ERK-dependent synaptic plasticity without changing spinal NLRP3 levels, while fully restoring NLRP3 overexpression and HO-1 downregulation in the amygdala. Sex-dependent activation of antioxidant pathways was also observed in the spinal cord. These results suggest that H2 modulates sensory and affective disturbances through distinct central mechanisms that differ by brain region and biological sex.
HRW suppresses spinal oxidative stress and ERK-dependent synaptic plasticity, restores NLRP3 inflammasome overactivation and HO-1 downregulation in the amygdala, and activates sex-dependent antioxidant pathways in the spinal cord.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/41977237