水素水の経口摂取による静脈グラフト動脈化後の内膜肥厚抑制効果：ラットモデルを用いた検討
Intimal hyperplasia is a leading cause of arterialized vein graft failure. This study examined whether oral intake of hydrogen-rich water (HW), produced by immersing a magnesium stick in tap water, could reduce neointima formation in a rat aortic interposition graft model. Lewis rats received tap water, HW, or degassed water (DW) starting on the day of surgery. At six weeks post-grafting, animals given tap water or DW showed pronounced intimal hyperplasia with elevated oxidative injury markers, whereas HW-treated animals exhibited significantly reduced neointima formation. One week after surgery, HW recipients demonstrated better endothelial integrity and lower platelet and leukocyte aggregation. Upregulation of intercellular adhesion molecule mRNAs was attenuated in HW-treated grafts, as was activation of p38 mitogen-activated protein kinase, MMP-2, and MMP-9. In cultured rat smooth muscle cells (A7r5), 24-hour hydrogen exposure reduced cell migration. These findings indicate that HW consumption suppresses multiple pathological processes underlying vein graft intimal hyperplasia.
Hydrogen-rich water reduces oxidative injury and suppresses activation of p38 MAPK, MMP-2, and MMP-9, while attenuating intercellular adhesion molecule upregulation, thereby inhibiting smooth muscle cell migration and neointima formation.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/22287575