水素の医療応用に関する臨床的考察：多様な投与経路と疾患モデルへの効果
Molecular hydrogen has demonstrated beneficial effects across a range of disease models, with ischemia-reperfusion injury being among the most studied. Research in this field has expanded rapidly as evidence accumulates. Notably, hydrogen exerts its effects through multiple administration routes—including gaseous inhalation, oral ingestion, intravenous infusion, and topical application—indicating broad versatility. This review consolidates recent findings on hydrogen-rich water and evaluates prospects for its clinical use. Attention has also grown around hydrogen's role as a gaseous signaling molecule capable of modulating oxidative stress pathways, and further mechanistic and clinical investigations are anticipated.
Molecular hydrogen is thought to selectively neutralize reactive oxygen species, particularly hydroxyl radicals, thereby suppressing oxidative stress signaling and conferring cytoprotective effects.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/27777424