胃食道逆流症における水素豊富水の酸化的血漿状態への影響：新たな生物学的視点
Gastroesophageal reflux disease (GERD) is associated with elevated systemic oxidative stress. In this clinical trial, 84 GERD patients were assigned to receive either proton pump inhibitor (PPI) combined with electrolysed reduced water (ERW) rich in molecular hydrogen, or PPI combined with tap water, over a 3-month period. Oxidative and antioxidant markers—including d-ROMs, biological antioxidant potential (BAP), superoxide anion, nitric oxide, and malondialdehyde—were measured alongside the GERD-Health Related Quality of Life Questionnaire. Patients in the ERW group showed significant improvements in oxidative balance and reductions in heartburn and regurgitation scores. Spearman correlation analysis revealed meaningful associations between laboratory parameters and symptom scores, suggesting that ERW supplementation alongside PPI contributes to improved cellular redox status and quality of life in GERD patients.
Molecular hydrogen in electrolysed reduced water is thought to scavenge reactive oxygen species such as superoxide anion, thereby reducing d-ROMs and malondialdehyde levels while enhancing biological antioxidant potential, ultimately restoring the oxidative-antioxidant balance in GERD patients.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/29512923