水素水摂取による化学療法誘発性神経障害性疼痛の軽減：腸内細菌叢調節を介したメカニズムの検討
This animal study investigated the effects of hydrogen-rich water (HRW) on chemotherapy-induced neuropathic pain (CINP) using C57BL/6J mice administered oxaliplatin. Mice were assigned to four groups combining normal or hydrogen-rich water with saline or oxaliplatin injections. Mechanical paw withdrawal thresholds were assessed on days 0, 5, 10, 15, and 20. On day 20, fecal samples were analyzed for gut microbial diversity and composition. Inflammatory cytokines (TNF-α, IL-6), oxidative stress markers (hydroxyl radical, peroxynitrite), lipopolysaccharide (LPS), and Toll-like receptor 4 (TLR4) were quantified in dorsal root ganglia, L4–6 spinal cord segments, and serum. HRW consumption significantly reduced oxaliplatin-induced hyperalgesia, decreased microbial diversity, restructured gut microbiota composition, normalized inflammatory and oxidative stress markers, and suppressed LPS and TLR4 levels. These findings suggest that HRW may mitigate CINP through gut microbiota-mediated regulation of the LPS-TLR4 signaling pathway.
HRW alters gut microbiota diversity and composition, reducing LPS translocation and subsequent TLR4 activation, which in turn suppresses inflammatory cytokines (TNF-α, IL-6) and oxidative stress markers (hydroxyl radical, peroxynitrite) in dorsal root ganglia and spinal cord segments.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/33732014