分子状水素によるクロロタロニル農薬分解の調節機構
This study examined how molecular hydrogen (H₂) influences the degradation of the fungicide chlorothalonil (CHT) in plant systems. H₂ application accelerated CHT breakdown without compromising its antifungal properties. Pharmacological experiments demonstrated that brassinosteroids (BRs) mediate this response, as H₂ stimulated BR biosynthesis and upregulated detoxification-related enzyme genes in tomato and Arabidopsis. Arabidopsis plants overexpressing the hydrogenase gene CrHYD1 from Chlamydomonas reinhardtii showed elevated endogenous H₂, increased BR levels, and enhanced CHT degradation. Removal of endogenous BRs produced opposing results, confirming BR dependence. The effect was observed across multiple crop species including Chinese cabbage, cucumber, radish, alfalfa, rice, and rapeseed, suggesting broad applicability. These findings indicate that both exogenous and endogenous H₂ can promote CHT degradation through a BR-dependent detoxification pathway, pointing toward potential agricultural applications of hydrogen.
H₂ stimulates brassinosteroid (BR) biosynthesis, which in turn upregulates genes encoding detoxification enzymes, thereby accelerating chlorothalonil breakdown within plant tissues.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/34583156