分子状水素は多様な疾患の根本原因に作用する「機関銃」型の医療ガスである
Most pharmaceuticals in contemporary medicine address symptoms rather than underlying causes and carry unavoidable adverse effects. Molecular hydrogen (H2), by contrast, selectively neutralizes two potent reactive oxygen species—hydroxyl radical (·OH) and peroxynitrite (ONOO⁻)—thereby acting on the fundamental pathology shared by numerous diseases. This review argues that ·OH-driven oxidative stress within mitochondria underlies a wide range of conditions, and that chronic inflammation is similarly rooted in ·OH activity. Because H2 can simultaneously address this common pathological origin across multiple disease states, it represents a conceptually distinct category of medical gas. Multiple clinical studies have reported an absence of adverse effects, further differentiating H2 from conventional pharmacological agents. The authors use the metaphor of a broad-coverage weapon to contrast H2's multi-target action against the single-target precision of conventional drugs.
H2 selectively scavenges hydroxyl radicals (·OH) and peroxynitrite (ONOO⁻), suppressing ·OH-induced oxidative stress in mitochondria and thereby addressing a shared root mechanism of multiple diseases and chronic inflammation.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/36204788