経口投与用シリコンナノ粒子による分子状水素の生成特性に関する検討
As interest in molecular hydrogen for biomedical applications has grown, safer and more efficient delivery strategies have become a research priority. This study evaluated the hydrogen-generating capacity of silicon particles produced via centrifugal chemical vapor deposition (cCVD). These particles react with water through a redox mechanism to release H₂ in situ. At physiological pH 7.4, generation rates reached up to 1310 ml/g with an 82% yield. An in vitro oral administration model demonstrated that exposure to artificial gastric juice did not impair hydrogen output, supporting gastrointestinal compatibility. However, surface carbon coatings and the addition of surfactants or albumin substantially inhibited H₂ generation. Egg white reduced but did not completely block production. Overall, cCVD-derived silicon particles appear promising as an oral H₂ delivery platform, though surface modification strategies require careful consideration to preserve generating efficiency.
Silicon particles undergo a redox reaction with water to produce H₂ in situ at physiological pH. The generated H₂ acts as an antioxidant by neutralizing reactive oxygen species, including damaging hydroxyl radicals.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/36351504