水素水と純水が歯周炎の炎症指標・酸化ストレス・口腔内細菌叢に与える影響：系統的レビューとメタ解析
A meta-analysis was conducted to evaluate the effects of hydrogen-rich water (HRW) compared with pure water on periodontal and peri-implant conditions. Seventeen randomized controlled trials involving 304 participants, published before March 2022, were identified across seven major databases. Pooled analyses showed that HRW significantly reduced IL-1β (SMD = −0.73), TNF-α (SMD = −2.51), IL-6 (SMD = −1.31), 8-hydroxyguanosine (SMD = −1.61), and reactive oxygen metabolites (SMD = −0.49), while glutathione peroxidase activity increased (SMD = 2.5). Oral pathogenic bacterial activity was also markedly suppressed (SMD = −0.91). Overall bias risk across included studies was rated as medium to low. These findings indicate that HRW exerts measurable anti-inflammatory, antioxidant, and antimicrobial effects in patients with periodontal disease.
HRW selectively scavenges reactive oxygen species, thereby reducing pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and oxidative stress markers while upregulating glutathione peroxidase activity and suppressing oral pathogenic bacterial proliferation.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36388830