熱傷皮膚の再生における肥満細胞の役割と分子状水素の効果
The regenerative mechanisms governing the fibrous components of dermal connective tissue remain incompletely understood. This study examined the contribution of mast cells (MCs) to collagen fiber regeneration in a second-degree burn wound model, comparing hydrogen-rich water and a hydrogen-containing ointment. Thermal injury elevated the MC population in skin and triggered systemic extracellular matrix remodeling. Application of molecular hydrogen promoted dermal fibrous component formation and accelerated wound closure, with collagen fibrillogenesis intensification comparable to that achieved by a conventional therapeutic ointment. Reductions in damaged skin area correlated with extracellular matrix remodeling. These findings suggest that MC secretory activation may represent a key mechanism through which molecular hydrogen exerts its biological effects on burn wound repair, with potential relevance for clinical application following thermal injury.
Molecular hydrogen activates mast cell secretory activity, promoting collagen fibrillogenesis and extracellular matrix remodeling, which accelerates dermal regeneration in burn wounds.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36986447