亜鉛-鉄一次電池構造による胃内水素放出制御が肥満関連2型糖尿病のインスリン抵抗性を改善する
Chronic systemic inflammation is a central driver of insulin resistance (IR) in obesity-associated type 2 diabetes (T2D). Conventional hydrogen delivery approaches are limited by insufficient dosage and short tissue exposure. This study developed a Zn-Fe primary battery micro/nanostructure that accelerates zinc hydrolysis in gastric acid, enabling controlled H2 release over approximately 3 hours—aligned with the gastric emptying window in mice. The Fe-to-Zn ratio was tuned to regulate the H2 release rate. In vivo imaging confirmed that H2 generated in the stomach accumulated at high concentrations in IR-relevant tissues (liver, adipose tissue, skeletal muscle) for a prolonged period compared with hydrogen-rich water. Daily oral administration at 200 mg/kg in leptin-deficient (ob/ob) mice significantly improved IR and reduced systemic inflammation. No apparent toxicity was observed at high doses, supporting the safety profile of this delivery platform.
The Zn-Fe galvanic micro/nanostructure accelerates zinc hydrolysis in gastric acid, generating sustained high-dose H2 over ~3 hours. H2 accumulates in liver, adipose, and skeletal muscle, scavenging reactive oxygen species and suppressing systemic inflammation, thereby reducing insulin resistance.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/38045569