肥満における分子状水素の役割：GLP-1・イリシン・PGC-1αを介した代謝改善の可能性
This article examines the potential role of molecular hydrogen (H2) in addressing obesity-related metabolic disturbances. The discussion centers on three key metabolic regulators: glucagon-like peptide-1 (GLP-1), irisin, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). These factors are involved in energy homeostasis, lipid metabolism, and mitochondrial biogenesis. The paper proposes that H2 may exert beneficial metabolic effects in obesity by modulating these pathways, though the precise mechanisms and clinical evidence require further investigation.
H2 is proposed to improve energy metabolism and mitochondrial function in obesity by upregulating GLP-1 secretion, increasing irisin expression, and activating PGC-1α, collectively modulating lipid and glucose homeostasis.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/40251025