H₂
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anti-inflammatory
743 papers
Delivery-method distribution
hydrogen-rich water: 254
inhalation: 140
mixed routes: 129
not specified: 61
in vitro: 61
injection / infusion: 60
topical application: 17
animal model: 15
hydrogen bath: 6
Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.
2016 ・ Oxid Med Cell Longev ・ PMID 27413421
mixed routes
not assessed
review
Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
2016 ・ Neurochem Res ・ PMID 27386874
injection / infusion
positive
animal study
Nitric oxide is involved in hydrogen gas-induced cell cycle activation during adventitious root formation in cucumber.
2016 ・ BMC Plant Biol ・ PMID 27352869
hydrogen-rich water
positive
in vitro study
Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model.
2016 ・ Exp Ther Med ・ PMID 27284352
inhalation
positive
animal study
Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice.
2016 ・ J Neuroimmunol ・ PMID 27138092
hydrogen-rich water
positive
animal study
Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis.
2016 ・ PLoS One ・ PMID 27115738
mixed routes
positive
in vitro study
Effects of hydrogen-rich water on depressive-like behavior in mice.
2016 ・ Sci Rep ・ PMID 27026206
hydrogen-rich water
positive
animal study
Nitric oxide is required for hydrogen gas-induced adventitious root formation in cucumber.
2016 ・ J Plant Physiol ・ PMID 27010347
hydrogen-rich water
positive
in vitro study
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
2016 ・ Sci Rep ・ PMID 26905012
inhalation
positive
animal study
Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways.
2016 ・ Chin J Physiol ・ PMID 26875562
mixed routes
positive
in vitro study
Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
2016 ・ Shock ・ PMID 26849632
inhalation
positive
animal study
Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats.
2016 ・ Pediatr Pulmonol ・ PMID 26845501
mixed routes
positive
animal study
Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.
2016 ・ Brain Res ・ PMID 26826009
injection / infusion
positive
animal study
Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.
2016 ・ Biochem Pharmacol ・ PMID 26774456
hydrogen-rich water
positive
animal study
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.
2016 ・ Sci Rep ・ PMID 26739257
in vitro
positive
in vitro study
Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.
2016 ・ Free Radic Biol Med ・ PMID 26709014
hydrogen-rich water
positive
animal study
Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury.
2016 ・ Brain Res ・ PMID 26705611
inhalation
positive
animal study
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
2016 ・ FEBS J ・ PMID 26683671
mixed routes
positive
animal study
Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.
2016 ・ Neurochem Res ・ PMID 26537817
injection / infusion
positive
animal study
Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
2016 ・ Biochim Biophys Acta ・ PMID 26488087
in vitro
positive
in vitro study
[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].
2015 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 27132459
injection / infusion
positive
animal study
Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
2015 ・ Antioxidants (Basel) ・ PMID 26783840
hydrogen-rich water
positive
human observational study
[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].
2015 ・ Seikagaku ・ PMID 26571560
mixed routes
not assessed
review
Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.
2015 ・ J Clin Biochem Nutr ・ PMID 26566302
hydrogen-rich water
positive
animal study
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw.
2015 ・ Ther Clin Risk Manag ・ PMID 26508867
injection / infusion
not assessed
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