敗血症による臓器障害に対する分子状水素の保護効果に関するレビュー
Since 2007, research into the biological protective properties of molecular hydrogen has expanded across numerous disease areas, including cerebral infarction, ischemia-reperfusion injury, Parkinson's disease, type 2 diabetes, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, and inflammatory conditions. This review focuses specifically on the effects of molecular hydrogen in the context of sepsis. Evidence from animal studies indicates that hydrogen administration influences basic vital signs, survival rates, and the function of multiple organs including the brain, lungs, liver, kidneys, and small intestine. The underlying mechanisms appear to involve suppression of pro-inflammatory cytokine release and attenuation of oxidative stress-mediated tissue damage. Through these actions, hydrogen may reduce multi-organ dysfunction associated with sepsis and improve overall survival outcomes, suggesting its potential as a future investigational approach in this setting.
Molecular hydrogen is thought to reduce sepsis-related multi-organ damage by suppressing pro-inflammatory cytokine release and decreasing oxidative stress-induced tissue injury, thereby preserving organ function and improving survival.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/27413421