H₂
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anti-inflammatory
743 papers
Delivery-method distribution
hydrogen-rich water: 254
inhalation: 140
mixed routes: 129
not specified: 61
in vitro: 61
injection / infusion: 60
topical application: 17
animal model: 15
hydrogen bath: 6
Intravenous infusion of H2-saline suppresses oxidative stress and elevates antioxidant potential in Thoroughbred horses after racing exercise.
2015 ・ Sci Rep ・ PMID 26493164
injection / infusion
positive
animal study
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.
2015 ・ Med Gas Res ・ PMID 26483953
mixed routes
not assessed
review
Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
2015 ・ Toxicol Lett ・ PMID 26276082
in vitro
positive
in vitro study
Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.
2015 ・ Int Immunopharmacol ・ PMID 26253656
in vitro
positive
in vitro study
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
2015 ・ Free Radic Biol Med ・ PMID 26117323
mixed routes
positive
animal study
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
2015 ・ J Thorac Cardiovasc Surg ・ PMID 26095621
hydrogen-rich water
positive
animal study
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
2015 ・ Cardiovasc Pathol ・ PMID 25979689
hydrogen-rich water
positive
animal study
Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.
2015 ・ Free Radic Res ・ PMID 25947958
mixed routes
positive
animal study
Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
2015 ・ Mol Med Rep ・ PMID 25936373
mixed routes
positive
human case report
Molecular hydrogen: An inert gas turns clinically effective.
2015 ・ Ann Med ・ PMID 25936365
mixed routes
not assessed
review
Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
2015 ・ BMC Neurosci ・ PMID 25925889
hydrogen-rich water
positive
animal study
Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?
2015 ・ Med Hypotheses ・ PMID 25920542
not specified
not assessed
other
Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
2015 ・ Brain Res ・ PMID 25920370
hydrogen-rich water
positive
animal study
Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase.
2015 ・ Shock ・ PMID 25895142
in vitro
positive
in vitro study
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
2015 ・ World J Gastroenterol ・ PMID 25892869
hydrogen-rich water
positive
animal study
Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
2015 ・ Clin Exp Ophthalmol ・ PMID 25801048
in vitro
positive
in vitro study
Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.
2015 ・ Methods Enzymol ・ PMID 25747486
mixed routes
not assessed
review
Targeting molecular hydrogen to mitochondria: barriers and gateways.
2015 ・ Pharmacol Res ・ PMID 25720951
not specified
not assessed
review
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.
2015 ・ Mol Cell Biochem ・ PMID 25707580
mixed routes
positive
animal study
Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.
2015 ・ Arch Gynecol Obstet ・ PMID 25681223
in vitro
mixed
in vitro study
Potential ghrelin-mediated benefits and risks of hydrogen water.
2015 ・ Med Hypotheses ・ PMID 25649854
hydrogen-rich water
not assessed
other
Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury.
2015 ・ Shock ・ PMID 25643010
inhalation
positive
animal study
Molecular hydrogen in sports medicine: new therapeutic perspectives.
2015 ・ Int J Sports Med ・ PMID 25525953
mixed routes
not assessed
review
Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats.
2015 ・ Anesthesiology ・ PMID 25501899
injection / infusion
positive
animal study
A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection).
2014 ・ Med Gas Res ・ PMID 25671079
not specified
not assessed
review
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