ミトコンドリア疾患改善の可能性を持つ新規抗酸化物質としての分子状水素
Mitochondria represent a primary site of reactive oxygen species generation, and both acute and sustained oxidative stress contribute to tissue injury, numerous diseases, and aging. This review consolidates findings from over 38 diseases and physiological conditions in which molecular hydrogen has been evaluated since the landmark 2007 Nature Medicine publication. Multiple administration routes are discussed, including gas inhalation, oral hydrogen-rich water, bathing, intravenous or intraperitoneal hydrogen-rich saline, ocular drops, and intestinal bacterial production. Beyond direct antioxidant activity, hydrogen also exhibits anti-inflammatory and anti-allergic properties. Preliminary clinical data suggest that hydrogen-rich water consumption may ameliorate pathological features of mitochondrial disorders. Despite these encouraging findings, the precise molecular mechanisms by which small quantities of hydrogen exert such broad biological effects remain to be fully elucidated.
Molecular hydrogen is proposed to selectively neutralize highly reactive oxygen species such as hydroxyl radicals, while also modulating anti-inflammatory and anti-allergic pathways, thereby reducing overall oxidative stress burden.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/21621588