水素水摂取がラット実験的歯周炎モデルに及ぼす影響
Reactive oxygen species (ROS) are implicated in periodontitis progression. Using a rat model in which ligature placement around maxillary molars induced periodontitis over 4 weeks, this study evaluated the effects of hydrogen-rich water consumed as drinking water. Animals receiving plain water exhibited a time-dependent rise in serum ROS, polymorphonuclear leukocyte infiltration, and alveolar bone loss. In contrast, hydrogen-rich water intake suppressed serum ROS elevation and reduced 8-hydroxydeoxyguanosine and nitrotyrosine expression in periodontal tissue. Osteoclast differentiation and mitogen-activated protein kinase (MAPK) inflammatory signaling were also attenuated in the hydrogen-rich water group. These findings suggest that hydrogen-rich water consumption may reduce gingival oxidative stress and slow periodontitis progression.
Hydrogen-rich water scavenges ROS, reducing oxidative stress markers (8-OHdG, nitrotyrosine) in periodontal tissue, and suppressing MAPK-mediated inflammatory signaling as well as osteoclast differentiation, thereby limiting alveolar bone loss.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/22092571