水素飽和生理食塩水がラット糖尿病・インスリン抵抗性モデルに及ぼす酸化ストレス軽減効果
Using rat models of diabetes mellitus (induced by high-fat/high-carbohydrate diet plus low-dose streptozotocin) and insulin resistance (induced by high-glucose/high-fat diet), this study examined the effects of daily hydrogen-saturated saline administration over eight weeks. Compared with both pioglitazone-treated and normal saline-treated control groups, hydrogen-saturated saline produced greater reductions in blood glucose and lipid levels and improved insulin sensitivity. Oxidative stress markers showed a significant decrease in malondialdehyde (MDA) alongside elevated superoxide dismutase (SOD) and glutathione (GSH) levels. These findings suggest that hydrogen-saturated saline may ameliorate insulin resistance and diabetic metabolic disturbances primarily through suppression of oxidative stress and enhancement of endogenous antioxidant defenses.
Hydrogen-saturated saline is proposed to scavenge reactive oxygen species, thereby reducing lipid peroxidation (MDA) and upregulating antioxidant enzymes SOD and GSH, which collectively attenuate oxidative stress and restore insulin sensitivity.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/22800834