水素水投与がチオアセトアミド誘発性肝性脳症ラットの肝脳連関障害を安定化させる効果の検討
Hepatic encephalopathy (HE) is a neuropsychiatric disorder arising from liver cirrhosis or failure, in which hyperammonemia, oxidative stress, neuroinflammation, and neuronal apoptosis collectively drive disease progression. Using intraperitoneal thioacetamide administration to establish a rat HE model, this study evaluated the effects of hydrogen-rich water on behavioral, biochemical, and histopathological outcomes. Hydrogen-rich water administration resulted in improved behavioral performance, reduced blood ammonia levels, attenuated liver function impairment, and alleviated pathological changes in both liver and brain tissues. Measurements in plasma, prefrontal cortex, and hippocampus revealed significant suppression of systemic and local oxidative stress, inflammatory responses, and neuronal apoptosis. These findings suggest that hydrogen-rich water may stabilize liver-brain axis disturbances in HE through coordinated anti-inflammatory, antioxidant, and anti-apoptotic mechanisms.
Hydrogen-rich water suppresses oxidative stress and inflammatory signaling in the prefrontal cortex and hippocampus while reducing neuronal apoptosis, thereby stabilizing liver-brain axis disturbances in thioacetamide-induced hepatic encephalopathy.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/40410340