水素水がグルタチオンペルオキシダーゼを介してGanoderma lucidumの形態・成長・二次代謝に与える影響
Using acetic acid (HAc) as an oxidative stressor in the medicinal fungus Ganoderma lucidum, this study examined how 5% hydrogen-rich water (HRW) influences ROS levels, mycelial morphology, growth, and secondary metabolite biosynthesis. HRW administration reduced ROS accumulation, preserved biomass and polar mycelial growth, and suppressed secondary metabolism under HAc-induced stress. These effects were contingent on restoration of the glutathione system, as GPX-deficient strains and wild-type strains treated with the GPX inhibitor mercaptosuccinic acid showed no response to HRW. Conversely, GPX-overexpressing strains displayed enhanced resistance to HAc-induced oxidative stress. The findings indicate that glutathione peroxidase is an essential mediator of HRW's regulatory actions on fungal physiology and secondary metabolism.
HRW restores the glutathione system through glutathione peroxidase (GPX), thereby suppressing HAc-induced ROS overproduction and regulating mycelial morphology, growth, and secondary metabolite biosynthesis in G. lucidum.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/27554678