フリーラジカル過剰産生状態における分子状水素の予防・治療的応用に関するレビュー
Excessive generation of oxygen free radicals is considered a shared pathological mechanism across numerous disease states. Hydroxyl and nitrosyl radicals cause biomolecular damage either directly or through chain reactions. Molecular hydrogen (H2) selectively neutralizes these potent oxidants within cells, diffusing rapidly into tissues without disrupting normal redox signaling or metabolic reactions. Beyond direct radical scavenging, H2 modulates gene expression to reduce oxidative stress and exhibits both anti-inflammatory and anti-apoptotic properties. Accumulating evidence from animal models and clinical observations supports H2 as a promising antioxidant agent against oxidative stress-related pathologies. This review highlights the mechanistic basis and practical applicability of H2 in settings characterized by excessive free radical production, particularly hydroxyl and nitrosyl species.
H2 selectively reacts with hydroxyl and nitrosyl radicals, rapidly penetrating cells and tissues without disturbing redox signaling, while also reducing oxidative stress through gene expression modulation, anti-inflammatory effects, and inhibition of apoptosis.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/27643933