不活性ガスから医療ガスへ：分子水素の医学的応用と作用機序に関するレビュー
Hydrogen, the most abundant element in the universe, was long regarded as chemically inert with no biological relevance. Accumulating evidence has since repositioned molecular hydrogen as a biologically active molecule with antioxidant, anti-inflammatory, and anti-apoptotic properties, as well as the capacity to modulate gene expression and intracellular signaling pathways. This review surveys research advances across multiple medical disciplines, examining how hydrogen exerts its effects at the molecular level and discussing the mechanistic hypotheses proposed to explain its diverse biological activities. The transition of hydrogen from an inert gas to a molecule of medical interest represents a significant conceptual shift in biomedical research.
Molecular hydrogen is proposed to act as a selective antioxidant while also suppressing inflammatory responses, inhibiting apoptosis, and modulating gene expression and signal transduction pathways, collectively contributing to its broad biological effects.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/29497488