救急・集中治療領域における水素ガスの医療応用に関するレビュー
Hydrogen gas has been reported to exert beneficial effects across a broad spectrum of conditions, ranging from acute disorders such as ischemia-reperfusion injury and hemorrhagic shock to chronic conditions including metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Antioxidant and anti-inflammatory mechanisms have been proposed, yet the precise molecular target of hydrogen gas remains unidentified. This review summarizes findings from research conducted through an industry-academia collaborative center focused on hydrogen medicine, covering areas such as acute myocardial infarction, cardiopulmonary arrest syndrome, contrast-induced acute kidney injury, and hemorrhagic shock within the context of emergency and critical care medicine.
Hydrogen gas is proposed to act via antioxidant and anti-inflammatory pathways, though its specific molecular target has not yet been identified.
For inhalation applications of molecular hydrogen, the lower flammability limit (LFL) deserves careful handling. The classical 4% figure applies to closed-system mixtures; the practical inhalation-environment threshold is 10%. Even pure-hydrogen output (the UFL 75% paradox) passes through the flammable range at the air–gas boundary. High-concentration (66% / 100%) inhalers are documented in the Japanese Consumer Affairs Agency accident-information database and are not recommended.
See also:
https://h2-papers.org/en/papers/29657720