myocardial infarction

28 papers

Research evidence summary

Q: Does molecular hydrogen help with myocardial infarction?

A: Of 28 peer-reviewed papers, 22 reported a positive effect (the most common), 2 limited/mixed, 0 negative, 4 not assessed. Study mix: 5 human (1 RCT), 19 animal/basic, 4 meta-analysis or synthesis. The most studied delivery route is inhalation. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	5	of which RCT	1
Animal/basic	19	Synthesis/meta	4
Reported effect	positive 22 ・ limited/mixed 2 ・ negative 0 ・ not assessed 4

Read the safety notes →

Delivery-method distribution

inhalation: 10 hydrogen-rich water: 8 injection / infusion: 5 mixed routes: 4 not specified: 1

Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats.
2026 ・ Biomater Adv ・ PMID 41671925

injection / infusion positive animal study
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status.
2025 ・ Antioxidants (Basel) ・ PMID 41462618

inhalation positive animal study
Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.
2025 ・ Int J Mol Sci ・ PMID 41373725

mixed routes not assessed review
Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction.
2025 ・ In Vivo ・ PMID 40010949

not specified positive human case report
The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.
2024 ・ Int J Mol Sci ・ PMID 39063126

mixed routes not assessed review
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
2024 ・ Sci Rep ・ PMID 38745034

mixed routes positive animal study
Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
2023 ・ Bull Exp Biol Med ・ PMID 37773571

inhalation positive animal study
Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
2023 ・ ESC Heart Fail ・ PMID 37602925

injection / infusion positive animal study
The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure.
2023 ・ Life (Basel) ・ PMID 36836774

inhalation positive animal study
Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.
2023 ・ Med Gas Res ・ PMID 36204784

inhalation positive human randomized controlled trial
Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
2022 ・ Bull Exp Biol Med ・ PMID 36210415

inhalation positive human observational study
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
2021 ・ Korean J Physiol Pharmacol ・ PMID 34697262

hydrogen-rich water positive animal study
Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.
2020 ・ J Clin Biochem Nutr ・ PMID 33041520

inhalation mixed human case report
Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury in Rats.
2020 ・ J Bioenerg Biomembr ・ PMID 32472432

hydrogen-rich water positive animal study
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
2020 ・ Curr Mol Med ・ PMID 31702499

hydrogen-rich water positive animal study
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
2019 ・ J Bioenerg Biomembr ・ PMID 31768722

hydrogen-rich water positive animal study
Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury.
2019 ・ Int J Med Sci ・ PMID 31588191

hydrogen-rich water positive animal study
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
2019 ・ Molecules ・ PMID 31159153

mixed routes not assessed review
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
2019 ・ Curr Mol Med ・ PMID 30907314

hydrogen-rich water positive animal study
Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium.
2019 ・ Mol Cell Biochem ・ PMID 30830529

hydrogen-rich water positive animal study
Promising novel therapy with hydrogen gas for emergency and critical care medicine.
2018 ・ Acute Med Surg ・ PMID 29657720

inhalation not assessed review
Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling.
2018 ・ BMC Cardiovasc Disord ・ PMID 29433438

injection / infusion positive animal study
Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention.
2017 ・ Can J Physiol Pharmacol ・ PMID 28350967

injection / infusion positive animal study
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.
2017 ・ Circ J ・ PMID 28321000

inhalation mixed human observational study
Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
2016 ・ Shock ・ PMID 26849632

inhalation positive animal study