Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment.

Abstract

This review examines mast cells as a prospective cellular target through which molecular hydrogen (H₂) may modulate the local tissue microenvironment. H₂ appears to influence the processing of pro-inflammatory constituents within the mast cell secretome and their subsequent release into the extracellular matrix. Such modulation could meaningfully alter integrated-buffer metabolic capacity and reshape the immune landscape of local tissues. The authors discuss several candidate mechanisms underlying H₂ biological activity and consider their relevance to conditions including malignant neoplasms, diabetes mellitus, viral hepatitis, and mental or behavioral disorders. The review concludes that mast cell-centered pathways represent a promising avenue for translating H₂ research findings into clinical applications.

Mechanism

H₂ is proposed to regulate the processing and extracellular matrix release of pro-inflammatory components within the mast cell secretome, thereby modulating the immune landscape and integrated-buffer metabolism of local tissue microenvironments.