分子状水素とヘムオキシゲナーゼ1の併用によるパクリタキセル誘発性末梢神経障害の抑制効果（マウスモデル）
This study investigated the combined effects of hydrogen-rich water (HRW) and the heme oxygenase-1 (HO-1) inducer cobalt protoporphyrin IX (CoPP) on paclitaxel (PTX)-induced peripheral neuropathy in male C57BL/6 mice. Low-dose co-administration produced faster and greater reductions in mechanical and thermal allodynia compared with either agent alone, and also suppressed anxiodepressive-like behaviors. In the amygdala and dorsal root ganglia, the combination attenuated NLRP3 inflammasome activation, 4-hydroxynonenal accumulation, and pro-inflammatory mediator mRNA levels. Concurrently, expression of NRF2, HO-1, superoxide dismutase 1, glutathione S-transferase mu 1, and glutamate-cysteine ligase modifier subunit was elevated, while BACH1 protein levels declined. These findings indicate a synergistic interaction between the HO-1 and H2 systems in modulating oxidative stress and inflammation associated with PTX-induced neuropathy.
Co-administration of HRW and CoPP activates the NRF2 antioxidant pathway, upregulating HO-1, SOD1, and glutathione-related enzymes while reducing BACH1 protein and suppressing NLRP3 inflammasome activation and 4-hydroxynonenal accumulation in dorsal root ganglia and amygdala.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39061924