水素水が腸内細菌叢を介してトリプトファン代謝を調節しアリール炭化水素受容体を活性化することで喘息気道炎症を軽減する
This study examined the effects of hydrogen-rich water (HRW) on asthmatic mice using 16S rRNA sequencing and serum metabolomics to characterize shifts in gut microbiota composition and circulating metabolites. HRW administration increased the relative abundance of Ligilactobacillus and Bifidobacterium and elevated serum levels of indole-3-acetic acid (IAA), a metabolite of microbial tryptophan catabolism. Both in vivo and in vitro experiments indicated that IAA activates the aryl hydrocarbon receptor (AhR) signaling pathway, which was associated with reduced airway inflammation in asthmatic mice. These findings suggest that HRW reshapes the gut microbiome, promotes IAA production, and engages AhR signaling as a mechanism underlying its anti-inflammatory effects on the gut-lung axis in asthma.
HRW increases gut Bifidobacterium and Ligilactobacillus abundance, elevating microbially derived indole-3-acetic acid (IAA), which activates the aryl hydrocarbon receptor (AhR) signaling pathway and thereby suppresses airway inflammation in asthmatic mice.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39147072