水素水とメマンチンによる慢性放射線誘発性脳損傷に対する長期神経保護効果：行動・組織・分子レベルの解析
This animal study examined the 60-day effects of hydrogen-rich water (HRW) on chronic radiation-induced brain injury (RIBI) in male Sprague-Dawley rats subjected to 20 Gy whole-brain X-ray irradiation. Five groups were compared: control, irradiation alone, irradiation plus memantine, irradiation plus HRW, and irradiation plus combined treatment. HRW administration was associated with reduced anxiety-like behavior and improved memory and learning performance. Histopathological evaluation revealed attenuation of neuronal swelling, degeneration, and loss, along with increased dendritic spine density and neurogenesis. 18F-FDG PET/CT imaging demonstrated that elevated hippocampal glucose uptake observed in irradiated rats was normalized by HRW. Transcriptomic and molecular analyses identified modulation of CD44, CD74, SPP1, and Wnt1, implicating MIF, Wnt, and SPP1 signaling pathways. Serum CD44 concentrations were reduced in HRW-treated animals, suggesting its utility as a biomarker. The combined HRW and memantine group showed additive benefits on several endpoints.
HRW appears to modulate CD44, CD74, SPP1, and Wnt1 expression via MIF, Wnt, and SPP1 signaling pathways, thereby reducing oxidative stress and neuroinflammation while enhancing neuroplasticity in chronically irradiated brain tissue.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/40867844