H₂
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endothelial function
35 papers
Delivery-method distribution
inhalation: 10
hydrogen-rich water: 10
mixed routes: 4
injection / infusion: 4
in vitro: 4
not specified: 1
hydrogen bath: 1
animal model: 1
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
2026 ・ Sci Rep ・ PMID 41582106
inhalation
positive
human observational study
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling.
2026 ・ Bioact Mater ・ PMID 41334374
in vitro
positive
in vitro study
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status.
2025 ・ Antioxidants (Basel) ・ PMID 41462618
inhalation
positive
animal study
Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide.
2025 ・ J Thorac Dis ・ PMID 41376930
mixed routes
positive
animal study
Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report.
2025 ・ In Vivo ・ PMID 41167678
hydrogen-rich water
positive
human case report
Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.
2025 ・ Eur J Pharmacol ・ PMID 40845957
animal model
positive
animal study
[Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].
2025 ・ Ter Arkh ・ PMID 40327618
inhalation
positive
human randomized controlled trial
Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults.
2025 ・ Biogerontology ・ PMID 40044939
hydrogen-rich water
not assessed
review
[Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen].
2024 ・ Ter Arkh ・ PMID 38713041
inhalation
positive
human randomized controlled trial
Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
2023 ・ Bull Exp Biol Med ・ PMID 37773571
inhalation
positive
animal study
[Hydrogen-rich water improves progressive sperm motility in rats by reducing oxidative stress and upregulating CLDN3 and SRD5A2 expressions].
2021 ・ Zhonghua Nan Ke Xue ・ PMID 37454313
hydrogen-rich water
positive
animal study
Inhalation of 2% Hydrogen Improves Survival Rate and Attenuates Shedding of Vascular Endothelial Glycocalyx in Rats with Heat Stroke.
2021 ・ Shock ・ PMID 34524269
inhalation
positive
animal study
Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice.
2021 ・ Biology (Basel) ・ PMID 33922704
hydrogen-rich water
positive
animal study
Effects of hydrogen as adjuvant treatment for unstable angina.
2021 ・ Exp Biol Med (Maywood) ・ PMID 33899541
mixed routes
positive
human randomized controlled trial
Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans.
2021 ・ J Therm Biol ・ PMID 33454037
hydrogen bath
positive
human observational study
Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model.
2020 ・ Shock ・ PMID 32804466
inhalation
positive
animal study
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
2020 ・ PLoS One ・ PMID 32470022
hydrogen-rich water
positive
human randomized controlled trial
Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
2020 ・ PLoS One ・ PMID 32302306
inhalation
positive
animal study
Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury.
2019 ・ Int J Med Sci ・ PMID 31588191
hydrogen-rich water
positive
animal study
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.
2018 ・ Sci Rep ・ PMID 30429524
hydrogen-rich water
positive
animal study
Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease.
2018 ・ Mol Med Rep ・ PMID 30320393
hydrogen-rich water
positive
animal study
Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.
2018 ・ Liver Transpl ・ PMID 30120877
injection / infusion
positive
animal study
Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.
2018 ・ Sci Rep ・ PMID 29321509
injection / infusion
positive
human observational study
[Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].
2017 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 28627348
injection / infusion
positive
animal study
[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].
2016 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 29920028
inhalation
positive
animal study
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