H₂
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anti-inflammatory
743 papers
Delivery-method distribution
hydrogen-rich water: 254
inhalation: 140
mixed routes: 129
not specified: 61
in vitro: 61
injection / infusion: 60
topical application: 17
animal model: 15
hydrogen bath: 6
[Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated encephalopathy].
2014 ・ Zhonghua Yi Xue Za Zhi ・ PMID 25573317
inhalation
positive
animal study
Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.
2014 ・ Vasc Health Risk Manag ・ PMID 25378931
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
2014 ・ Circulation ・ PMID 25366995
inhalation
positive
animal study
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
2014 ・ PLoS One ・ PMID 25251220
hydrogen-rich water
positive
animal study
Effects of hydrogen-rich water on aging periodontal tissues in rats.
2014 ・ Sci Rep ・ PMID 24985521
hydrogen-rich water
mixed
animal study
Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes.
2014 ・ Sci Rep ・ PMID 24975958
mixed routes
not assessed
animal study
Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.
2014 ・ Toxicol Appl Pharmacol ・ PMID 24967689
hydrogen-rich water
positive
animal study
Molecular hydrogen attenuates neuropathic pain in mice.
2014 ・ PLoS One ・ PMID 24941001
hydrogen-rich water
positive
animal study
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
2014 ・ Int Immunopharmacol ・ PMID 24929023
injection / infusion
positive
human randomized controlled trial
Hydrogen gas presents a promising therapeutic strategy for sepsis.
2014 ・ Biomed Res Int ・ PMID 24829918
inhalation
not assessed
review
Effect of hydrogen-rich water on acute peritonitis of rat models.
2014 ・ Int Immunopharmacol ・ PMID 24793096
hydrogen-rich water
positive
animal study
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
2014 ・ Pharmacol Ther ・ PMID 24769081
mixed routes
not assessed
review
Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats.
2014 ・ CNS Neurosci Ther ・ PMID 24685114
injection / infusion
positive
animal study
Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
2014 ・ Mol Cell Biochem ・ PMID 24652103
hydrogen-rich water
positive
animal study
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water.
2014 ・ BMC Complement Altern Med ・ PMID 24589018
hydrogen-rich water
positive
animal study
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
2014 ・ World J Gastroenterol ・ PMID 24587639
hydrogen-rich water
positive
animal study
Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.
2014 ・ Med Hypotheses ・ PMID 24529916
not specified
not assessed
other
Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.
2014 ・ Free Radic Biol Med ・ PMID 24509162
hydrogen-rich water
positive
animal study
Medical applications of breath hydrogen measurements.
2014 ・ Anal Bioanal Chem ・ PMID 24481621
not specified
not assessed
review
Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production.
2014 ・ J Hazard Mater ・ PMID 24413050
hydrogen-rich water
positive
in vitro study
Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.
2014 ・ J Bone Miner Metab ・ PMID 24196871
in vitro
positive
in vitro study
Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.
2013 ・ Sci Rep ・ PMID 24253616
hydrogen-rich water
positive
animal study
Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages.
2013 ・ Int J Surg ・ PMID 24148794
in vitro
positive
in vitro study
Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).
2013 ・ Int J Mol Sci ・ PMID 24132155
hydrogen-rich water
not assessed
review
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
2013 ・ Clin Transl Sci ・ PMID 24127924
hydrogen-rich water
mixed
human randomized controlled trial
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