H₂
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reactive oxygen species
774 papers
Delivery-method distribution
hydrogen-rich water: 224
in vitro: 135
inhalation: 133
mixed routes: 118
not specified: 75
injection / infusion: 58
topical application: 14
animal model: 12
hydrogen bath: 5
Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
2017 ・ Shock ・ PMID 28234792
inhalation
positive
animal study
Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.
2017 ・ BMC Musculoskelet Disord ・ PMID 28148301
injection / infusion
positive
animal study
Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet.
2017 ・ Nutrients ・ PMID 28098768
hydrogen-rich water
positive
animal study
Proteomic analysis provides insights into the molecular bases of hydrogen gas-induced cadmium resistance in Medicago sativa.
2017 ・ J Proteomics ・ PMID 27989938
hydrogen-rich water
positive
in vitro study
Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.
2017 ・ Shock ・ PMID 27918369
hydrogen-rich water
positive
animal study
Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment.
2017 ・ Hum Cell ・ PMID 27804028
in vitro
positive
in vitro study
Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.
2017 ・ J Microbiol Biotechnol ・ PMID 27780950
in vitro
positive
in vitro study
Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum.
2017 ・ Environ Microbiol ・ PMID 27554678
in vitro
positive
in vitro study
Molecular Hydrogen as a Neuroprotective Agent.
2017 ・ Curr Neuropharmacol ・ PMID 27281176
mixed routes
not assessed
review
[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
2016 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 29923387
injection / infusion
positive
animal study
[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].
2016 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 29920028
inhalation
positive
animal study
Molecular hydrogen: a therapeutic antioxidant and beyond.
2016 ・ Med Gas Res ・ PMID 28217294
not specified
not assessed
review
Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy.
2016 ・ J Physiol Pharmacol ・ PMID 28011948
inhalation
positive
animal study
Should hydrogen therapy be included in a musculoskeletal medicine routine?
2016 ・ F1000Res ・ PMID 28003879
mixed routes
not assessed
review
Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress.
2016 ・ Am J Transl Res ・ PMID 27830032
in vitro
positive
animal study
Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.
2016 ・ Free Radic Biol Med ・ PMID 27789293
mixed routes
positive
animal study
The Clinical Application of Hydrogen as a Medical Treatment.
2016 ・ Acta Med Okayama ・ PMID 27777424
mixed routes
not assessed
review
Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.
2016 ・ Oxid Med Cell Longev ・ PMID 27774116
animal model
positive
animal study
Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3.
2016 ・ Chin Med J (Engl) ・ PMID 27647193
hydrogen-rich water
positive
animal study
Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.
2016 ・ Physiol Res ・ PMID 27643933
mixed routes
not assessed
review
The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-α in Macrophages.
2016 ・ Inflammation ・ PMID 27624060
in vitro
positive
in vitro study
Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.
2016 ・ Med Sci Monit ・ PMID 27606690
injection / infusion
not assessed
other
Molecular hydrogen suppresses activated Wnt/β-catenin signaling.
2016 ・ Sci Rep ・ PMID 27558955
mixed routes
positive
in vitro study
Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation.
2016 ・ mBio ・ PMID 27531909
in vitro
not assessed
other
Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
2016 ・ Circ J ・ PMID 27477846
in vitro
positive
in vitro study
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