低線量長期放射線照射によるマウスの行動・造血・生殖・脾臓リンパ球への障害に対する水素の防護効果
This mouse study examined whether molecular hydrogen (H₂) could mitigate multi-system damage arising from low-dose long-term gamma radiation (LDLTR). Animals received whole-body irradiation at doses of 0.1, 0.5, 1.0, or 2.0 Gy, and a comprehensive battery of assessments was conducted after the final exposure: body mass monitoring, forced swim test, open field test, chromosome aberration analysis, peripheral blood cell counts, sperm abnormality evaluation, lymphocyte transformation test, and histopathological examination. Across all dose levels, H₂-treated mice showed statistically significant improvements compared with radiation-only controls in behavioral performance, hematopoietic indices, reproductive parameters, and splenic lymphocyte function, indicating that H₂ exerts broad protective effects against LDLTR-induced injury in multiple biological systems.
H₂ is proposed to reduce radiation-induced oxidative stress and chromosomal aberrations, thereby attenuating functional impairment across hematopoietic, reproductive, and immune compartments following chronic low-dose gamma irradiation.
This study is at the animal-experiment stage. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/27774116