水素富化生理食塩水による放射線照射マウスの精子形成および造血機能の保護効果
This animal study examined whether pre-administration of hydrogen-rich saline could mitigate radiation-induced damage to spermatogenesis and hematopoiesis in BALB/c mice exposed to 60Co gamma irradiation. Spermatogenesis was evaluated by spermatid head counts and histological examination of seminiferous epithelium, while hematopoietic function was assessed via endogenous spleen colony formation (endoCFUs), bone marrow nucleated cell (BMNC) counts, and peripheral blood leukocyte levels. Mice receiving hydrogen-rich saline prior to irradiation showed increased spermatid head counts and preserved seminiferous epithelial integrity. Hematopoietic indices, including endoCFUs, BMNC, and peripheral leukocytes, were all significantly elevated compared to irradiated controls. These findings indicate that hydrogen-rich saline can partially preserve both reproductive and hematopoietic function following ionizing radiation exposure, likely through attenuation of radiation-induced oxidative stress.
Molecular hydrogen is proposed to selectively scavenge radiation-generated reactive oxygen species, particularly hydroxyl radicals, thereby reducing oxidative damage to seminiferous epithelium and hematopoietic progenitor cells in irradiated mice.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/22367121