水素水投与によるアスピリン誘発性胃粘膜障害に対する保護効果のラット実験的検討
This animal study examined whether hydrogen-rich water (HRW) could protect gastric mucosa from aspirin-induced damage in male rats divided into four groups: normal control, HRW alone, aspirin alone, and HRW plus aspirin. Gastric mucosal damage scores were markedly lower in the HRW-pretreated group compared with aspirin alone (2.10±0.437 vs 4.04±0.492, P<0.05). Oxidative stress markers MDA and MPO were significantly elevated by aspirin but suppressed by HRW pretreatment, while SOD activity was substantially higher in the HRW group (59.55±9.02 vs 37.94±8.44 nmol/mg prot). Inflammatory cytokines IL-6 and TNF-α in gastric tissue, as well as serum IL-1β and TNF-α, were all significantly reduced by HRW. Immunohistochemical analysis revealed that COX-2 expression in gastric tissue was considerably lower in the HRW-pretreated group (staining score 2.9±1.5 vs 8.4±2.1). These findings indicate that HRW exerts gastroprotective effects by attenuating oxidative stress, suppressing inflammatory mediators, and downregulating COX-2 expression.
HRW reduces oxidative stress in gastric tissue by lowering MDA and MPO levels while increasing SOD activity. Simultaneously, it suppresses pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) and downregulates COX-2 expression, collectively protecting the gastric mucosa from aspirin-induced injury.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/24587639